CBD And The Endocannabinoid System

CBD And The Endocannabinoid System

CBD And The Endocannabinoid System

The Endocannabinoid System is a network inside your body. It exerts influence over several bodily functions and helps keep everything in check. Whether you know it already or not, your body produces substances that are identical to the cannabinoids in hemp and marijuana. The Endocannabinoid System (ECS) uses these endocannabinoids to function.

Taking CBD boosts the amount of this cannabinoid in your system but your body is already making its own every day.

CBD And The Endocannabinoid System: Explaining The ECS

The ECS contains 3 major components: metabolic enzymes, endocannabinoids, and cannabinoid receptors.

Metabolic Enzymes

Metabolic enzymes produce endocannabinoids in the first place. They also break these endocannabinoids back down and eliminate them once they’ve served their purpose. Without these enzymes, we would possess an overabundance of endocannabinoids. This could negatively impact neuron communication.

Cannabinoid Receptors

In order for endocannabinoids to work at all job, they attach to receptors in your ECS. Your entire body is covered in cannabinoid receptors. Modern science is aware of two receptors at this point: CB2 and CB1. The CB1 receptors affect things like coordination and memory and they are mostly focused in the brain and nervous system. Conversely, CB2 receptors regulate the immune system and the body’s general state of balance.

When endocannabinoids bind to these receptors, they influence how these receptors function which alters communication in the body.


As already stated, endocannabinoids are substances your body creates every day. Most vertebrates produce endocannabinoids, actually.

Cannabinoids from the cannabis plant and our own endocannabinoids are identical chemical substances which are synthesized by the body. The 2 endocannabinoids that science understands the most are anandamide, which binds to the CB1 receptor, and 2 AG, which binds to the CB2 receptor. The endocannabinoids either inhibit or even encourage the generation of neurotransmitters, managing the conversations that occur between neurons.

Whether you take CBD or smoke cannabis or not, the endocannabinoids in your body are going about their business. They influence a variety of processes from how we perceive pain to how our digestive system is working.

CBD And The Endocannabinoid System: Science Discovers The ECS

If all that interests you, perhaps you’d like to know how we discovered the ECS in the first place.

In 1988, Allyn Howlett and William Devane found the original cannabinoid receptor inside a rat’s brain. Thereafter, these cannabinoid receptors proved to be plentiful within the human brain. There are actually more cannabinoid receptors than any other neurotransmitter receptors.
Shortly after this, scientists started utilizing an artificial form of THC in order to cure serious nausea and also to map the CB receptors in the human brain.
By 1990, Lisa Matsuda identified the DNA sequence which describes a THC receptor in rats. Afterwards, researchers had the ability to study precisely what substances triggered these receptors.
Furthermore, scientists created genetically altered mice that lacked the receptor. After they tested these rats they saw that they were correct: the rats didn’t feel any effects without the receptor. This demonstrated that the consequences of THC (memory loss during use, etc) emerge because it binds to receptors in the human brain.
In 1992 – 1993 the scientific community found one more cannabinoid receptor in 1993. It formed a part of the nervous and immune systems and also was dubbed CB2 (the CB receptors in the mind belong in the CB1 receptors). Unlike CB1s, CB2 receptors live in abundance in the blood vessels, spleen, liver, heart kidneys, bones, lymph cells as well as the reproductive organs.
However a curious, question remained – why do we’ve cannabinoid receptors within the 1st place?
The means to discover that answer was underway by 1992. Raphael Mechoulam isolated Anandamide, the initial endocannabinoid. NIMH investigators William Devane and Dr. Lumir Hanus verified these findings.
In 1995, another endocannabinoid emerged. Named 2 arachidonoylglycerol, this endocannabinoid links to both CB2 and CB1 receptors.

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